Quassin Synthesis Essay

Related Content:

  • Total Synthesis of the Sesquiterpenoid Periconianone A Based on a Postulated Biogenesis

    Journal of the American Chemical Society

    Liffert, Linden, and Gademann

    2017139 (45), pp 16096–16099

    Abstract: The first enantioselective total synthesis of the complex tricarbocyclic sesquiterpenoid periconianone A based on a postulated biogenesis is reported. Key elements of the synthetic route include the use of an isopropenyl group as a removable directing ...

    Abstract | Full Text HTML | PDF w/ Links | Hi-Res PDF

  • Total Synthesis of (−)-Himalensine A

    Journal of the American Chemical Society

    Shi, Michaelides, Darses, Jakubec, Nguyen, Paton, and Dixon

    2017139 (49), pp 17755–17758

    Abstract: The first enantioselective synthesis of (−)-himalensine A has been achieved in 22 steps. The synthesis was enabled by a novel catalytic, enantioselective prototropic shift/furan Diels–Alder (IMDAF) cascade to construct the ACD tricyclic core. A reductive ...

    Abstract | Full Text HTML | PDF w/ Links | Hi-Res PDF

  • Synthetic studies on quassinoids: total synthesis of (-)-chaparrinone, (-)-glaucarubolone, and (+)-glaucarubinone

    Journal of the American Chemical Society

    Grieco, Collins, Moher, Fleck, Gross

    1993115 (14), pp 6078–6093

    Abstract | Hi-Res PDF

  • Total Synthesis of Longeracinphyllin A

    Journal of the American Chemical Society

    Li, Zhang, Zhang, Chen, and Li

    2017139 (42), pp 14893–14896

    Abstract: The first and asymmetric total synthesis of longeracinphyllin A, a hexacyclic Daphniphyllum alkaloid, has been accomplished. A tetracyclic intermediate was prepared through silver-catalyzed alkyne cyclization and Luche radical cyclization. A phosphine-...

    Abstract | Full Text HTML | PDF w/ Links | Hi-Res PDF

  • Synthetic Studies on Quassinoids:  Total Synthesis and Biological Evaluation of (+)-Des-d-chaparrinone

    The Journal of Organic Chemistry

    Grieco and Speake

    199863 (17), pp 5929–5936

    Abstract: A total synthesis of des-d-chaparrinone (2), which lacks the ring D δ-lactone of (−)-chaparrinone (1) has been developed. The synthesis commences with the known, readily available tricyclic ketone 3 (R = Me). Elaboration of the configuration at C(5) ...

    Abstract | Full Text HTML | PDF w/ Links | Hi-Res PDF

  • Total Syntheses of (−)-Majucin and (−)-Jiadifenoxolane A, Complex Majucin-Type Illicium Sesquiterpenes

    Journal of the American Chemical Society

    Condakes, Hung, Harwood, and Maimone

    2017139 (49), pp 17783–17786

    Abstract: We report the first chemical syntheses of both (−)-majucin and (−)-jiadifenoxolane A via 10 net oxidations from the ubiquitous terpene (+)-cedrol. Additionally, this approach allows for access to other majucin-type sesquiterpenes, like (−)-jiadifenolide, (...

  • Related Content:

  • Total Syntheses of Scaparvins B, C, and D Enabled by a Key C–H Functionalization

    Journal of the American Chemical Society

    Ye, Qu, and Snyder

    2017139 (51), pp 18428–18431

    Abstract: The clerodane diterpene family possesses an impressive range of bioactivities and high synthetic challenge due to their unique amalgamation of rings, stereocenters, and oxygenation. Herein, we disclose the first total syntheses of three members, ...

    Abstract | Full Text HTML | PDF w/ Links | Hi-Res PDF

  • Total Synthesis of (−)-Himalensine A

    Journal of the American Chemical Society

    Shi, Michaelides, Darses, Jakubec, Nguyen, Paton, and Dixon

    2017139 (49), pp 17755–17758

    Abstract: The first enantioselective synthesis of (−)-himalensine A has been achieved in 22 steps. The synthesis was enabled by a novel catalytic, enantioselective prototropic shift/furan Diels–Alder (IMDAF) cascade to construct the ACD tricyclic core. A reductive ...

    Abstract | Full Text HTML | PDF w/ Links | Hi-Res PDF

  • Total Synthesis of Longeracinphyllin A

    Journal of the American Chemical Society

    Li, Zhang, Zhang, Chen, and Li

    2017139 (42), pp 14893–14896

    Abstract: The first and asymmetric total synthesis of longeracinphyllin A, a hexacyclic Daphniphyllum alkaloid, has been accomplished. A tetracyclic intermediate was prepared through silver-catalyzed alkyne cyclization and Luche radical cyclization. A phosphine-...

    Abstract | Full Text HTML | PDF w/ Links | Hi-Res PDF

  • Enantioselective Total Synthesis of (−)-Pavidolide B

    Journal of the American Chemical Society

    Zhang, Yan, Li, Gong, and Yang

    2017139 (40), pp 13989–13992

    Abstract: The enantioselective synthesis of (−)-pavidolide B (1) was achieved in a linear sequence of 10 steps. The key steps are (a) an enantioselective organocatalytic cyclopropanation; (b) a radical-based cascade annulation for the regio- and diastereo-selective ...

    Abstract | Full Text HTML | PDF w/ Links | Hi-Res PDF

  • Total Syntheses of (−)-Majucin and (−)-Jiadifenoxolane A, Complex Majucin-Type Illicium Sesquiterpenes

    Journal of the American Chemical Society

    Condakes, Hung, Harwood, and Maimone

    2017139 (49), pp 17783–17786

    Abstract: We report the first chemical syntheses of both (−)-majucin and (−)-jiadifenoxolane A via 10 net oxidations from the ubiquitous terpene (+)-cedrol. Additionally, this approach allows for access to other majucin-type sesquiterpenes, like (−)-jiadifenolide, (...

    Abstract | Full Text HTML | PDF w/ Links | Hi-Res PDF

  • Total Syntheses of (+)- and (−)-Tetrapetalones A and C

    Journal of the American Chemical Society

    Dhanjee, Kobayashi, Buergler, McMahon, Haley, Howell, Fujiwara, and Wood

    2017139 (42), pp 14901–14904

    Abstract: Described herein are syntheses of the naturally occurring polyketides (−)-tetrapetalones A and C and their respective enantiomers. The employed strategy involves initial assembly of a masked N-aryl tetramic acid which is advanced via a highly selective ...

    Abstract | Full Text HTML | PDF w/ Links | Hi-Res PDF

  • 0 comments

    Leave a Reply

    Your email address will not be published. Required fields are marked *